联系信息
mhillwig@sorizu.net

教育

  • B.S.宾夕法尼亚州立大学,2003年
  • Ph.D.,爱荷华州立大学,2008年

出版物

  • Awakawa T.; Mori, T.; Nakashima, Y.; Zhai, R.; Wong, C.P.; Hillwig, M.L.; 刘,X.; Abe, I. Molecular Insight into the Mg2+ -Dependent Allosteric Control of Indole Prenylation by Aromatic Prenyltransferase AmbP1. Angewandte Chemie International Edition 2018, 57 (23), 6810-6813.
  • 徐,M.; Hillwig, M.L.; Tiernan, M.S.; Peters, R.J. “Probing labdane-related diterpenoid biosynthesis in the fungal genus Aspergillus.” Journal of Natural Products 2017, 80 (2), 328-33.
  • 米切尔,. J.; 朱,问.; Maggiolo, A. O.; Ananth, N. R.; Hillwig, M. L.; 刘,X.; Boal, A. K. “Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.” Nature Chemical Biology 2016, 12 (8), 636-40.
  • Hillwig, M. L.; 朱,问.; Ittiamornkul K.; 刘,X. “Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules.” Angewandte Chemie International Edition 2016, 55 (19), 5780-4.
  • Mafu,年代.; Jia, M.; Zi, J.; 莫龙D.; 吴,Y.; 徐,M.; Hillwig, M. L.; Peters, R. J. “Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis.” Proceedings of the National Academy of Sciences of the U.S.A. 2016, 113 (9), 2526-2531.
  • 朱,问.; Hillwig, M. L.; Doi, Y.; 刘,X. “Aliphatic Halogenase Enables Late-Stage C-H Functionalization: Selective Synthesis of a Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity.生物化学,2016,17 (6),466-70.
  • 刘,X.; Hillwig, M. L.; Koharudin, L. M. I.; Gronenborn, A. M. 统一生物成因的歧义, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase.” Chemical Communications 2016, 52 (8), 1737-1740.
  • Ittiamornkul K.; 朱,问.; Gkotsi, D. S.; Smith, D. R. M.; Hillwig, M. L.; Nightingale, N.; Goss, R. J. M.; 刘,X. “Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids.化学科学,2015,6 (12),6836-6840.
  • Medema, M.H.; Kottmann, R; Yilmaz, P.; Cummings, M.; Biggins, J.B.; Blin, K.; de Bruijn I.; Chooi, Y.H.; Claesen, J.; Coates, R.C.; Cruz-Morales, P.; Duddela, S.; Düsterhus, S.; Edwards, D.J.; Fewer, D.P.; Garg, N.; Geiger, C.; Gomez-Escribano J.P.; Greule, A.; Hadjithomas, M.; Haines, A.S.; Helfrich, E.J.; Hillwig, M.L.; Ishida, K.; Jones, A.C.; et al. “Minimum Information about a Biosynthetic Gene cluster.” Nature Chemical Biology 2015, 11 (9), 625-31.
  • Mafu,年代.; Potter, K.C.; Hillwig, M.L.,肖特S,克里斯维尔J,彼得斯RJ. “Efficient heterocyclisation by (di)terpene synthases.” Chemical Communications 2015, 51 (70):13485-7.
  • Hillwig, M.L. & 刘,X. “A new family of iron-dependent halogenases acts on freestanding substrates.” Nature Chemical Biology 2014, 10 (11), 921-3.
  • 徐,M.; Hillwig, M.L.; Lane, A.L.; Tiernan, M.S.; Moore, B.S.; Peters, R.J. “Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola.” Journal of Natural Products 2014 77 (9), 2144-7.
  • Hillwig, M.L.; Fuhrman, H.A.; Ittiamornkul K.; et al. “Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in Stigonematalean Cyanobacterium Hapalosiphon welwitschii.生物化学,2014,15 (5),665-9.
  • 高,W.; Sun, H.-X.; Xiao, H.; Cui, G.; Hillwig, M. L.; et al. “Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza.BMC Genomics, 2014,28 (15):73.
  • Hillwig, M.L.; 朱,问; 刘,X. “Biosynthesis of Ambiguine Indole Alkaloids in Cyanobacterium Fischerella ambigua.[j] .化学工程学报,2014,29 (2),379 - 379.
  • 16. 郭,我.; Zhou, Y.J.希尔维格,M.L.; et al. “CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.” Proceedings of the National Academy of Sciences of the U.S.A. 2013, 110 (29), 12108-13.
  • 吴,Y.; 王,问.; Hillwig, M. L.; Peters, R. J. Picking sides: Distinct roles for CYP76M6 and -8 in rice oryzalexin biosynthesis. 生物化学学报,2013,32 (2):559 - 564.
  • 王,问.; Hillwig, M.L.; 吴,Y.; et al. CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism. 植物生理学报,2012,31 (3),344 - 344.
  • 王,问.; Hillwig, M.L.; Okada, K.; et al. “Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster.” Journal of Biological Chemistry 2012, 287 (9), 6159-68.
  • Hillwig, M.L.; 徐,M.; Toyomasu, T.; et al. “Domain loss has independently occurred multiple times in plant terpene synthase evolution.《澳门金沙博彩娱乐平台》. 2011, 68 (6), 1051-60.
  • Mafu,年代.; Hillwig, M. L.; Peters, R. J. 小说《拉达,13E-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii.生物化学,2011,12(13):1984-7.
  • 吴,Y.; Hillwig, M.L.; 王,问.; Peters, R.J. "Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7.”《生物工程学报》,2011年第5期,第3 - 4页.
  • 莫龙D.; Hillwig, M.L.; Mead, M.E.; Lowry, L.; Fulton, B.F.; Peters, R.J. “Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals.生物化学学报,2011,35 (3),589-95.
  • Hillwig, M.L.; Mann F.M.; Peters, R.J. “Diterpenoid biopolymers: new directions for renewable materials engineering.” 2011, 95 (2), 71-6.
  • 王,问.希尔维格,M.L.; Peters, R.J. "CYP99A3: Functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice.植物学报,2011,35 (1),87-95.
  • Maugel N.; Mann F.M.; Hillwig M.L.; Peters R.J.; Snider, B.B. “Synthesis of (±)-Nosyberkol (Isotuberculosinol, Revised Structure of Edaxadiene).” Organic Letters 2009, 2010, 12 (11), 2626-9.
  • 高,W.希尔维格·M.L.,黄磊.崔刚.、王旭.,孔杰.,杨斌.彼得斯·R.J. "A functional genomics approach to tanshinone biosynthesis provides stereochemical insights.《澳门十大博彩娱乐平台网址》,2009,11 (22),5170-3.
  • Birt D.F.维德勒希纳.P.锤子K.D.希尔维格·M.L.,魏杰.克劳斯·G.A.墨菲·P.A.等。. “Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents.” Pharmaceutical Biology 2009, 47 (8), 774-782.
  • Hillwig, M.L.; 锤,K.D.P.; Birt, D.F.; Wurtele, E.S. “Characterizing the Novel Metabolic Fingerprint and Anti-inflammatory Activity of Hypericum gentianoides.” Journal of Agricultural and Food Chemistry 2008, 56 (12), 4359-66.
  • 锤,K.D.P.; Hillwig, M.L.; Wurtele, E.S.; Birt, D.F. Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4-component system mimicking an Hypericum perforatum fraction. 植物化学学报,2008,29 (4):554 - 562.
  • 锤,K.D.P.; Hillwig, M.L.; Wurtele, E.S.; Birt, D.F. “Inhibition of prostaglandin E2 production by anti-inflammatory Hypericum perforatum extracts and constituents in RAW264.7小鼠巨噬细胞.” Journal of Agricultural and Food Chemistry 2007, 55 (18), 7323-31.
  • 徐,M.; Hillwig, M.L.; Prisic, S.; Coates, R.M.; Peters, R.J. “功能一致格?cation of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products.植物学报,2004,39 (3),309-18.

成就

  • 美国国立卫生研究院(NIH. Kirschstein National Research Service Award (NRSA) Individual Trainee Fellowship (F22) from 2004 to 2008.